Objective: In the absence of vaccines and effective pharmaceutical interventions, an economic way to deal with such a prolonged epidemic of COVID-19 is the need of the hour.Fever is a primary response of the immune system to infections, and it resembles the michel germain deauville disease termed jwara.Ayurveda describes immunity through bala (stre
We present the case of a patient with psoriatic arthritis (PsA) mutilans and spyderco urban occult axial involvement.The patient had suffered from PsA mutilans for more than a decade, with severe residual articular damage, but had been in clinical remission for years.Clinical axial involvement was never reported; however, magnetic resonance imaging
Abstract Background Paradoxical sleep deprivation (PSD) associated with copyright has been shown to enhance genital reflexes (penile erection-PE and ejaculation-EJ) in Wistar rats.Since hypertension predisposes males to erectile dysfunction, the aim of the present study was to investigate the effects of PSD on genital reflexes in the spontaneously
Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy.The complex is composed of an ORC1/4/5 motor module lobe
Abstract Background Childhood adversity places individuals in a vulnerable position, resulting in potentially enduring disadvantage across life domains like health and work.Studying the manifestation of this disadvantage is crucial for understanding which resources society can provide to mitigate or prevent it, which makes this subject a fundamenta